产品名称：CDK2 INHIBITOR III
Background Information: A cell-permeable purine analog that acts as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk2 (IC50 = 0.5 µM for Cdk2/A and Cdk2/E; 4.2 µM for Cdk1/B; 215 µM for Cdk4/D1). Inhibits other kinases only at much higher concentrations (IC50 > 1.25 mM for MAPK, PKA, and PKC). Shown to induce tumor cells growth arrest (IC50 = ~1.25-20 µM) in vitro and prevent neointima formation in vivo.
Empirical Formula: C20H28N6O3
Purity: ≥98% by HPLC
Gene Symbol: CDK2
Properties: Solubility: DMSO (10 mg/ml).
Presentation: White solid. Packaged under inert gas.
Sales Restrictions: Sold under license of U.S. Patents 6,617,331 and 6,803,371.
Storage Conditions: Shipped at Ambient Temperature. Store at +2 - 8°C.