Background Information: A cell-permeable and reversible cytotoxic agent that shows selective cytocidal activity against neoplastic cells and virally transformed cells. Selectively inhibits phosphatidylinositol-specific phospholipase C (PI-PLC; IC50 = 15 µM) but does not inhibit phosphatidylcholine-specific PLC or PLD. Promotes apoptosis in mitogen-activated, but not resting, T lymphocytes in a dose- and time-dependent manner. Also promotes rapid and selective apoptosis in human leukemic cells.
Molecular Weight: 523.7
Storage Conditions: Shipped at Ambient Temperature. Store at -20°C.
Properties: Solubility: DMSO (5 mg/ml), CHCl3 (50 mg/ml), Ethanol (5 mg/ml), or H2O. Material may form micelles in aqueous stock solutions, which may affect experimental results.
Empirical Formula: C27H58NO6P