Background Information: A cell-permeable non-thiol peptidomimetic that acts as a potent and selective inhibitor of geranylgeranyltransferase I (GGTase I). Blocks the geranyl-geranylation of Rap1A with an IC50 value that is over 60-fold lower than that required to disrupt the farnesylation of H-Ras (IC50 = 500 nM for Rap1A versus IC50 > 30 µM for H-Ras).
Molecular Weight: 470.6
Presentation: Off-white solid. Packaged under inert gas.
Storage Conditions: Shipped at Ambient Temperature. Store at -20°C.
Properties: Solubility: DMSO (200 mg/ml).
Gene Symbol: PGGT1B
Empirical Formula: C28H30N4O3