上海浩洋生物科技有限公司

 ISOGRANULATIMIDE|merck 371957-1MG
  • ISOGRANULATIMIDE|merck 371957-1MG
  • ISOGRANULATIMIDE|merck 371957-1MG

    参考价格: ¥3893.00
    品  牌:merck
    产品型号:371957-1MG (1MG)
    所在地区:上海
    上架时间:2013年04月27日
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    ISOGRANULATIMIDE|merck 371957-1MG
    产品名称:ISOGRANULATIMIDE
    产品货号:371957-1MG
    产品价格:¥3893
    产品规格:1MG
    Background Information: A cell-permeable alkaloid containing indole/maleimide/imidazole skeleton that acts as a potent, reversible and ATP-competitive inhibitor of Chk1 (IC50 = 100 nM) and GSK-3β (IC50 = 500 nM). Inhibits G2 DNA damage checkpoint-associated kinases, Chk2, Cdk1, and DNA-PK only at much higher concentrations (IC50 = 3 µM, 10 µM, and 10 µM, respectively). Only minimally affects the activities of a panel of 11 other kinases tested (IC50 ≥ 40 µM). When used in combination with ?-irradiation, it is also reported to selectively arrest the growth of MCF-7 cells lacking p53 function.
    Molecular Weight: 276.3
    Presentation: Dark red solid. Packaged under inert gas.
    Storage Conditions: Shipped Ambient Temperature, or on Blue Ice or Dry Ice. Store at +2 - 8°C.
    Properties: Solubility: DMSO (50 mg/ml).
    Empirical Formula: C15H8N4O2