Background Information: A highly potent cell-permeable and reversible inhibitor of glycogen synthase kinase-3β (GSK-3β; IC50 = 9 nM). Also inhibits Cdk1 (IC50 = 25 nM) and Cdk5 (IC50 = 20 nM) activities. Acts by binding to the ATP-binding pocket of these enzymes.
Molecular Weight: 403.2
Presentation: Dark red solid. Packaged under inert gas.
Storage Conditions: Shipped at Ambient Temperature. Store at -20°C.
Properties: Solubility: DMSO (100 mg/ml).
Gene Symbol: CDK1, CDK2, CDK3, CDK4, CDK5, CDK6, CDK7, CDK8, CDK9, CDK10