Background Information: A cell-permeable phytoestrogen that inhibits topoisomerase I-catalyzed DNA religation in HL-60 cells. Offers protection against Aβ25-35-induced cell death in neonatal cortical neurons. Its protective effects are comparable to that of estradiol. Blocks the Aβ-induced activation of caspase-2, -3, -8, and -9, and reduces NMDA-induced neuronal apoptosis. Reported to be a potent inhibitor of monoamine oxidases. Acts as an inhibitor of COX-1 activity (IC50 = 180 µM), and of transcriptional activation of COX-2 (IC50<15 µM).
Molecular Weight: 286.2
Presentation: Yellow solid. Packaged under inert gas.
Storage Conditions: Shipped at Ambient Temperature. Store at -20°C.
Properties: Solubility: DMSO (25 mg/ml) or Ethanol (20 mg/ml).
Gene Symbol: PTGS1, PTGS2
Empirical Formula: C15H10O6