上海浩洋生物科技有限公司

 MEK1/2 INHIBITOR
  • MEK1/2 INHIBITOR
  • MEK1/2 INHIBITOR

    参考价格: ¥1555.00
    品  牌:merck
    产品型号:444939-1MG (1MG)
    所在地区:上海
    上架时间:2013年05月02日
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    MEK1/2 INHIBITOR
    产品名称:MEK1/2 INHIBITOR
    产品货号:444939-1MG
    产品价格:¥1555
    产品规格:1MG
    Background Information: A cell-permeable vinylogous cyanamide that acts as a selective inhibitor of MEK1/2 (IC50 = 180 nM and 220 nM, respectively). Shown to inhibit AP-1 activity (IC50 = 2.03 µM). Inhibits ERK1, MKK3/p38, MKK4, JNK, and PKC activities at higher concentrations (IC50 > 10 µM). Reported to offer neuroprotection against ischemic brain injury in mice by selectively blocking ERK1/2 activation. Also suppresses IL-1β expression. Displays enhanced aqueous solubility compared to U0126 (Cat. No. 662005). Uncompetitive with respect to ATP. Supplied as a mixture of Z- and E-isomers.
    Molecular Weight: 335.4
    Presentation: Off-white solid. Packaged under inert gas.
    Properties: Solubility: DMSO (200 mg/ml) or Ethanol (10 mg/ml).
    Empirical Formula: C16H12F3N3S
    Storage Conditions: Shipped at Ambient Temperature. Store at -20°C.