产品名称：Anti-Human Ki-67 (clone 20Raj1) FITC
Isotype IgG1, kappa
Reactivity Canine, Human
Laser Blue Laser
Excite 488 nm
Reported Applications Intracellular Staining Followed by Flow Cytometric Analysis, Immunohistochemical Staining, Immunocytochemistry
Description: The monoclonal antibody 20Raj1 recognizes the human Ki-67 protein. Two isoforms of Ki-67 exist, a 345 and 395 kDa form that are expressed in dividing cells. Ki-67 is expressed in all cell types and is detectable during active phases of the cell cycle (G1, S, G2, and mitosis) but is absent from resting cells (G0). During interphase, Ki-67 expression is localized to the nucleus but redistributes to the chromosomes during mitosis and has specifically been found to associate with heterochromatin-bound proteins such as chromobox protein homolog 3 (CBX3). In studies of tumor cells, Ki-67 expression has been used as a marker for determining the fraction of proliferating cells within a given population of tumor cells.