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 Anti-Human TCL1 PE eBio1-21
  • Anti-Human TCL1 PE eBio1-21
  • Anti-Human TCL1 PE eBio1-21

    参考价格: ¥3588.00
    品  牌:eBioscience
    产品型号:12-6699-42 (100 tests)
    所在地区:上海
    上架时间:2012年12月31日
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    Anti-Human TCL1 PE eBio1-21
    产品名称:Anti-Human TCL1 PE eBio1-21
    规格:100 tests
    货号:12-6699-42
    厂商:eBioscience
    产品介绍:
    Also known as: T Cell Leukemia/Lymphoma 1, TCL-1
    Clone: eBio1-21 (1-21)
    Host Mouse
    Isotype IgG2b, kappa
    Reactivity Human
    Conjugate PE
    Laser Blue Laser, Green Laser, Yellow-Green Laser
    Emit 575 nm
    Excite 488 - 561 nm
    Reported Applications Intracellular Staining Followed by Flow Cytometric Analysis
    Description: The eBio1-21 antibody reacts with human T cell leukemia/lymphoma 1 (TCL1), a 14 kDa proto-oncogene product with a suggested role in intracellular regulation of T cell signalling. TCL1 was identified as the oncogene located at the 14q32.1 chromosome breakpoint region in T-cell prolymphocytic leukemia (T-PLL). In T-PLL, TCL1 is overexpressed as a result of an inversion or a reciprocal translocation, by juxtaposition to the T-cell receptor promoter/enhancer elements. TCL1 binds to the pleckstrin homology domain of Akt (protein kinase B) family proteins, which facilitates Akt dimerization and activity. By increasing Akt activity TCL1 may enhance the serine/threonine phosphorylation of major Akt signaling substrates, such as Ikk complex, mTOR, BAD, p70S6 kinase, FOXO transcription factors, and GSK3β. These substrates regulate cellular differentiation, growth, survival, and metabolism.
    eBioscience 12-6699-42 Anti-Human TCL1 PE eBio1-21 (1-21) 100 tests 3588
    eBioscience 12-6699-41 Anti-Human TCL1 PE eBio1-21 (1-21) 25 tests 1548