产品名称：anti-mouse CD8a FG Biotin 53-6.7
Also known as: CD8 alpha, Ly-2, Ly-35, Ly-B, Lyt-2
Isotype IgG2a, kappa
Conjugate Functional Grade Biotin (low endotoxin, azide-free)
Reported Applications Flow Cytometric Analysis, Immunohistochemical Staining of Frozen Tissue Sections
Description: The 53-6.7 monoclonal antibody reacts with the mouse CD8a molecule. CD8a is an approximately 32-34 kDa cell surface receptor expressed either as a heterodimer with the CD8 β chain (CD8 αβ) or as a homodimer (CD8 αα). A majority of thymocytes and a subpopulation of mature αβ TCR T cells express CD8 αβ while γδ TCR T cells, a subpopulation of intestinal intraepithelial lymphocytes (IELs) and dendritic cells express CD8 αα. CD8 binds to MHC class I and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells.