上海浩洋生物科技有限公司

 anti-mouse DC-SIGN Biotin 5H10
  • anti-mouse DC-SIGN Biotin 5H10
  • anti-mouse DC-SIGN Biotin 5H10

    参考价格: ¥2748.00
    品  牌:eBioscience
    产品型号:13-2091-82 (100 ug)
    所在地区:上海
    上架时间:2013年01月09日
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    anti-mouse DC-SIGN Biotin 5H10
    产品名称:anti-mouse DC-SIGN Biotin 5H10
    规格:100 ug
    货号:13-2091-82
    厂商:eBioscience
    产品介绍:
    Also known as: DCSIGN, CIRE
    Clone: 5H10
    Host Rat
    Isotype IgG2a
    Reactivity Mouse
    Conjugate Biotin
    Reported Applications Flow Cytometric Analysis
    Description: The 5H10 antibody was generated by immunization with a peptide derived from the extracellular region of mouse CIRE/DC-SIGN (CD209). CIRE/DC-SIGN was identified by its expression on CD8α- dendritic cells and plasmacytoid predendritic cells, and is the closest homologue of human DC-SIGN. Human DC-SIGN was originally identified in human placenta for its ability to bind the HIV envelope protein gp120 in a CD4-independent manner. CIRE/DC-SIGN is a 33 kDa type II transmembrane C-type lectin protein. It contains a C-terminal, extracellular, Carbohydrate Recognition Domain (CRD) that is predicted to bind mannose and other carbohydrates in a Ca2+ dependent manner. It has been postulated that CIRE/DC-SIGN may play a role in T-dendritic cell interactions through binding with members of the ICAM family. CIRE/DC-SIGN is differentially expressed by sub-populations of dendritic cells and preliminary data suggest that its expression varies depending on the activation state of the host. CIRE/DC-SIGN is down-regulated in spleen-derived dendritic cell cultures supplemented with GM-CSF. While human DC-SIGN is predominantly expressed in dendritic cells, CIRE/DC-SIGN mRNA has also been detected in B cells. The 5H10 monoclonal antibody does not cross-react with the closely related SIGNR1, SIGNR2, SIGNR3 or SIGNR4.
    eBioscience 13-2091-82 anti-mouse DC-SIGN Biotin 5H10 100 ug 2748
    eBioscience 13-2091-80 anti-mouse DC-SIGN Biotin 5H10 25 ug 1188