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 Anti-Mouse gp49 Receptor (clone H1.1) Functional Grade Purified
  • Anti-Mouse gp49 Receptor (clone H1.1) Functional Grade Purified
  • Anti-Mouse gp49 Receptor (clone H1.1) Functional Grade Purified

    参考价格: ¥3588.00
    品  牌:eBioscience
    产品型号:16-5784-85 (500 ug)
    所在地区:上海
    上架时间:2013年01月10日
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    Anti-Mouse gp49 Receptor (clone H1.1) Functional Grade Purified
    产品名称:Anti-Mouse gp49 Receptor (clone H1.1) Functional Grade Purified
    规格:500 ug
    货号:16-5784-85
    厂商:eBioscience
    产品介绍:
    Host Armenian Hamster
    Isotype IgG
    Reactivity Mouse
    Conjugate Functional Grade Purified (low endotoxin, azide-free)
    Reported Applications Functional Assays
    Description: The monoclonal antibody H1.1 recognizes gp49, a receptor with structural similarities to the PIR (paired Ig-activating receptors) and ILT/KIR(killer inhibitory receptors) family of proteins. Two closely linked genes on mouse chromosome 10 encode the related proteins gp49A and gp49B. These two receptors are almost 90% identical in their extracellular regions but differ in their cytoplasmic domains; gp49B contains an ITAM domain while gp49A does not and is extremely short. Expression of gp49 was originally identified on mast and LAK (IL-2 activated NK) cells. Expression on LAK cells has been shown to be predominantly gp49B with only a small amount of gp49A. Additionally gp49 is found on myeloid cells. Detailed function is not known but gp49B can inhibit cellular activation. The monoclonal antibody H1.1 recognizes both gp49A and gp49B. The H1.1 antibody has been shown to have functional activity: when crosslinked along with anti-NK1.1 it can prevent cytokine release in KY-2 cells.