上海浩洋生物科技有限公司

 anti-mouse Granzyme B Biotin 16G6
  • anti-mouse Granzyme B Biotin 16G6
  • anti-mouse Granzyme B Biotin 16G6

    参考价格: ¥1308.00
    品  牌:eBioscience
    产品型号:13-8822-80 (25 ug)
    所在地区:上海
    上架时间:2013年01月10日
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    anti-mouse Granzyme B Biotin 16G6
    产品名称:anti-mouse Granzyme B Biotin 16G6
    规格:25 ug
    货号:13-8822-80
    厂商:eBioscience
    产品介绍:
    Also known as: GrzB, GrB
    Clone: 16G6
    Host Rat
    Isotype IgG2b, kappa
    Reactivity Mouse
    Conjugate Biotin
    Reported Applications Intracellular Staining Followed by Flow Cytometric Analysis, Western Blotting
    Description: The 16G6 antibody reacts with mouse Granzyme B (GrB) which is a member of the granzyme serine protease family. GrB is found in the granules of cytotoxic T cells and NK cells. Granzyme B has also been described as CGL1 (cathepsin G-like-1), a serine protease expressed only in cytotoxic T-lymphocytes after cell activation. GrB has been called CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1) based on identification of mRNA in various cytotoxic T cells, but not observed in non-cytotoxic lymphoid cells. GrB is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells. The receptor involved has been identified as mannose 6-phosphate receptor. This receptor functions as a death receptor for granzyme B during cytotoxic T cell-induced apoptosis.