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 anti-mouse/human ZAP-70 Purified 1E7.2
  • anti-mouse/human ZAP-70 Purified 1E7.2
  • anti-mouse/human ZAP-70 Purified 1E7.2

    参考价格: ¥2148.00
    品  牌:eBioscience
    产品型号:14-6695-82 (100 ug)
    所在地区:上海
    上架时间:2013年01月15日
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    anti-mouse/human ZAP-70 Purified 1E7.2
    产品名称:anti-mouse/human ZAP-70 Purified 1E7.2
    规格:100 ug
    货号:14-6695-82
    厂商:eBioscience
    产品介绍:
    Also known as: ZAP70
    Clone: 1E7.2
    Host Mouse
    Isotype IgG1, kappa
    Reactivity Human
    Conjugate Purified
    Description: The 1E7.2 antibody reacts with human and mouse ZAP-70, the TCRζ-associated protein-70. ZAP-70 is a cytosolic protein tyrosine kinase (PTK) and a member of the Syk family of proteins. It is expressed in T and NK cells and is required for TCR signaling and development. ZAP-70 interacts with the TCR complex by binding to tyrosine-phosphorylated immunoreceptor tyrosine-based activation motifs (ITAMs) present in the invariant subunits of the TCR complex. Following activation, ZAP-70 is phosphorylated on several tyrosine residues by two mechanisms; an autophosphorylation and a transphosphorylation by the Src family tyrosine kinase Lck1-3. Tyrosine phosphorylation of ZAP-70 correlates to its increased kinase activity and triggers downstream signaling events. Mutations in ZAP-70 have been shown to result in a form of Severe Combined Immunodeficiency Syndrome (SCID) in humans. 1E7.2 was generated against a KLH-peptide sequence corresponding to the human ZAP-70 amino acid residues 282-307. While ZAP-70 is normally expressed in T and NK cells, several recent studies have also shown high correlation of ZAP-70 positive expression with mutated IgVH expression in B-chronic lymphocytic leukemia (CCL). In conclusion, the expression of ZAP-70, which can be measured by intracellular flow cytometry, may serve as a prognostic marker for B-CLL.
    eBioscience 14-6695-82 anti-mouse/human ZAP-70 Purified 1E7.2 100 ug 2148
    eBioscience 14-6695-80 anti-mouse/human ZAP-70 Purified 1E7.2 25 ug 948