上海浩洋生物科技有限公司

 anti-mouse/rat ICOS (CD278) PE-Cy5 C398.4A
  • anti-mouse/rat ICOS (CD278) PE-Cy5 C398.4A
  • anti-mouse/rat ICOS (CD278) PE-Cy5 C398.4A

    参考价格: ¥3228.00
    品  牌:eBioscience
    产品型号:15-9949-82 (100 ug)
    所在地区:上海
    上架时间:2013年01月15日
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    anti-mouse/rat ICOS (CD278) PE-Cy5 C398.4A
    产品名称:anti-mouse/rat ICOS (CD278) PE-Cy5 C398.4A
    规格:100 ug
    货号:15-9949-82
    厂商:eBioscience
    产品介绍:
    Clone: C398.4A
    Host Armenian Hamster
    Isotype IgG
    Reactivity Mouse, Rat
    Conjugate PE-Cy5
    Laser Blue Laser, Green Laser, Yellow-Green Laser
    Emit 670 nm
    Excite 488 - 561 nm
    Description: The C398.4A monoclonal antibody reacts with ICOS (Inducible Costimulatory molecule), also known as H4/CRP-1/AILIM, and cross-reacts with mouse and rat ICOS. ICOS is a T cell specific activation molecule and a third member of the CD28/CTLA-4 family. A dimer of 47-57 kDa, ICOS is expressed on activated T cells, has potent costimulatory activity for T cell activation and proliferation and is required for humoral immune response. ICOS binds to its ligand on activated APC including B cells called B7h/B7RP-1, is thought to play a protective role in inflammatory autoimmune diseases and be involved in the development of Th2 cells. C398.4A is reported to display strong costimulation of proliferation of T cell clones, intermediate costimulation on activated T cells, and weak costimulation on fresh resting T cells. It is a good costimulator of IL-10 production especially from pre-activated cells that express high level of H4/ICOS. The epitope recognized by C398.4A is different from that bound by the ICOSL (i.e., C398.4A does not block binding of ICOSL).
    eBioscience 15-9949-82 anti-mouse/rat ICOS (CD278) PE-Cy5 C398.4A 100 ug 3228
    eBioscience 15-9949-81 anti-mouse/rat ICOS (CD278) PE-Cy5 C398.4A 50 ug 2028