上海浩洋生物科技有限公司

 Anti-Mouse/Rat IL-17A APC eBio17B7
  • Anti-Mouse/Rat IL-17A APC eBio17B7
  • Anti-Mouse/Rat IL-17A APC eBio17B7

    参考价格: ¥2268.00
    品  牌:eBioscience
    产品型号:17-7177-81 (50 ug)
    所在地区:上海
    上架时间:2013年01月15日
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    Anti-Mouse/Rat IL-17A APC eBio17B7
    产品名称:Anti-Mouse/Rat IL-17A APC eBio17B7
    规格:50 ug
    货号:17-7177-81
    厂商:eBioscience
    产品介绍:
    Also known as: Interleukin-17A, Cytotoxic T-lymphocyte-associated antigen 8, CTLA-8
    Clone: eBio17B7
    Host Rat
    Isotype IgG2a, kappa
    Reactivity Mouse, Rat
    Conjugate APC
    Laser Red Laser
    Emit 660 nm
    Excite 633 - 647 nm
    Reported Applications Intracellular Staining Followed by Flow Cytometric Analysis
    Description: The eBio17B7 antibody reacts with mouse and rat IL-17A with no recognition of IL-17F. Interleukin-17A (IL-17A) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. The cDNA encoding human IL-17A was isolated from a library of CD4+ T cells; the encoded protein exhibits 72 percent amino acid identity with HVS13 , an open reading frame from a T lymphotropic Herpesvirus saimiri, and 63 percent with mouse CTLA-8 (cytotoxic T-lymphocyte associated antigen-8). Human IL-17A exists as glycosylated 20-30 kD homodimers. High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells. IL-17A enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. Human IL-17A also stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse IL-17A receptor.