产品名称：anti-human AITR/GITR PE eBioAITR
Also known as: TNFRSF18, activation-inducible TNFR family member
Isotype IgG1, kappa
Laser Blue Laser, Green Laser, Yellow-Green Laser
Excite 488 - 561 nm
Reported Applications Flow Cytometric Analysis
Description: The monoclonal antibody reacts with human AITR, Activation Inducible TNFR family member, an approximately 25 kDa member of the TNFR superfamily. AITR mRNA is detected in lymph node, peripheral blood leukocytes and weakly in spleen. AITR mRNA expression was upregulated within 24 hour on PMA/ionomycin or PHA stimulated PBMC. At the protein level, AITR is expressed by a small population of activated PBMC. AITR associates with TRAF1, TRAF2 and TRAF3 and induces nuclear factor NF-κB activation via TRAF2. Recently TL6 (AITRL) has been reported as the ligand for AITR. Interaction of AITR with AITRL is important for cross-talk between T lymphocytes and endothelial cells.