产品名称：Human FGF basic (FGF-2) Recombinant Protein
Also known as: FGF basic 147, fibroblast growth factor beta
Purity Greater than or equal to 98%, as determined by SDS-PAGE
Molecular Mass 20 kDa
Endotoxin Level Less than 0.01 ng/ug cytokine as determined by the LAL assay.
Reported Applications Cytokine Bioassays
Description: Fibroblast Growth Factor basic (FGF-b, also known as FGF-2) is a member of the FGF family, a highly conserved family of 16-34 kDa heparin-binding proteins. FGF-b exists in several isoforms, and although they are equally active, only the 18 kDa form is secreted while the 23 kDa form localizes to the nucleus. They share four common tyrosine kinase receptors, FGFR 1-4, and require the binding of a second surface protein, the ubiquitously expressed heparan sulfate proteoglycan, in order to fully activate these receptors. FGF family members affect the proliferation, differentiation, mobility, and survival of several cell types, including fibroblasts, osteoblasts, smooth muscle cells, and neuroblasts. FGF-b expression has been detected in several cell types, including fibroblasts, macrophages, endothelial cells, epithelial cells, and neurons. It lacks the signal sequence peptide necessary for the ER/Golgi pathway, indicating that secretion occurs via an alternate pathway. They are particularly important in embryonic development as triggers of neurogenesis, angiogenesis, and neovascularization.
eBioscience 14-8986-80 Human FGF basic (FGF-2) Recombinant Protein 25 ug 1800
eBioscience 14-8986-62 Human FGF basic (FGF-2) Recombinant Protein 5 ug 600