上海浩洋生物科技有限公司

Human IL-8 Single-Use ELISA RSG Standard

Human IL-8 Single-Use ELISA RSG Standard

参考价格:¥960.00
品  牌:eBioscience
产品型号:39-8089-65 (4 pack)
所在地区:华东 上海
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Human IL-8 Single-Use ELISA RSG Standard
产品名称:Human IL-8 Single-Use ELISA RSG Standard
规格:4 pack
货号:39-8089-65
厂商:eBioscience
产品介绍:
Also known as: Interleukin-8, CXCL8
Reactivity Human
Reported Applications ELISA, ELISA Recombinant Standard
Description: Human IL-8 (CXCL8) is a pro-inflammatory member of the CXC chemokine family. It is synthesized as a 99 amino acid precursor protein that is further processed into one of four isoforms, with the most common being 72 or 77 amino acids in length. IL-8(77) is secreted primarily by endothelial cells and is thought to be a less potent neutrophil activator than the other forms. It is present at high levels during fetal development, where it mediates angiogenesis rather than inflammation. The predominant form present in adults is IL-8(72), which is expressed by monocytes, macrophages, epithelial cells, and fibroblasts in response to inflammatory stimuli, environmental stress, and steroid hormones. IL-8(72) is essential for the activation and recruitment of neutrophils to sites of inflammation, and has also been found to influence T cell migration. Signaling occurs through the G-protein coupled receptors CXCR1 or CXCR2. IL-8 transcripts are often upregulated in tumors, and it is associated with tumor angiogenesis and metastasis.