产品名称：Mouse IL-17F (Clone: RN17)
Also known as: Interleukin-17F, IL17F
Isotype IgG1, kappa
Conjugate Functional Grade Purified (low endotoxin, azide-free)
Reported Applications Cytokine Neutralization
Description: The monoclonal antibody RN17 reacts with and inhibits the bioactivity of mouse IL-17F. IL-17F is a 37kD homodimer of the IL-17 family and a signature Th17 marker. Of all the six IL-17 family members, IL-17F and IL-17A share the strongest homology (50% amino acid identity), and the two genes are located in the same chromosomal region. Recent studies have demonstrated coordinated regulation of IL-17A and IL-17F during Th17 differentiation. Expression of IL-17F and IL-17A has been detected in activated human peripheral blood lymphocytes, specifically by activated human CD4+ T cells. In addition to IL-17A, differentiated Th17 cells also produce IL-17F and IL-22 upon re-activation. Like IL-17A, IL-17F has been linked with inflammatory diseases. IL-17F and IL-17A expression has been observed in tissue samples from various autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, psoriasis, inflammatory bowel disease, and asthma. IL-17F treatment of airway epithelium, vein endothelial cells, and fibroblasts has been reported to induce expression of IL-6, IL-8, GRO-α, ENA-78, TGF-β, MCP-1, G-CSF, GM-CSF, and ICAM-1.
eBioscience 16-7473-82 Mouse IL-17F (Clone: RN17) 100 ug 2148
eBioscience 16-7473-85 Mouse IL-17F (Clone: RN17) 500 ug 5748