产品名称：IL-1β (mouse), ELISA kit
规格：1 x 96 wells
Long Term Storage: -20°C
Alternative Name: Interleukin-1β
Sensitivity: < 3 pg/ml (range 31.25 - 1,000 pg/ml)
Application: For the quantitative determination of IL-1β in culture supernatants, plasma, and serum of mouse origin.
Crossreactivity Proteins: Cross reactivities: mouse IL-1β (100%). Unaffected by mouse IL-1α, IL-2, IL-4, IL-6, IL-10, TNF-α, and GM-CSF; human IL-1α and IL-1β, IL-8; or bovine IL-1β. Does not cross react with rat IL-1β (12%).
Kit/Set Contains: Microtiter plate, SA-HRP concentrate, SA-HRP dilution buffer, Biotinylated antibody, Standard, Standard diluent, Wash buffer concentrate, TMB Substrate, Stop solution
Miscellaneous/General: The interleukin-1 (IL-1) cytokine family consists of IL-1α, IL-1β, and IL-1Rα (receptor antagonist) which are expressed primarily by endothelial cells and activated macrophages. IL-1α and IL-1β elicit pro-inflammatory cytokine production and cellular activation, and are the primary mediators of hypothalamic regulation that results in fever. IL-1α and IL-1β signals are transmitted via a dual subunit IL-1 receptor composed of IL-1R1 and the IL-1 receptor accessory protein (IL-1RAcP). IL-1RAcP is vital to IL-1 signaling, as it recruits the IL-1 receptor-associated kinase (IRAK) to the receptor complex, initiating NF-κB pathway activation.