产品名称：Bmf (NT), pAb
Long Term Storage: +4°C
Immunogen: Synthetic peptide corresponding to the sequence near the C-terminus of human Apaf1. The sequence differs from that of mouse Apaf1 by one amino acid.
Western Blot (2µg/ml, HepG2 or 293 cell lysates can be used for positive control)
Optimal conditions must be determined individually for each application.
Specificity: Recognizes human and mouse Bmf. Detects a band of ~25kDa by Western blot.
Purity Detail: Peptide affinity purified.
Formulation: Liquid. In PBS containing 0.02% sodium azide.
Miscellaneous/General: Bmf (Bcl-2 modifying factor) is a member of the Bcl-2 family of apoptotic proteins. The BH3 domain in Bmf is required both for binding to Bcl-2 proteins and for triggering apoptosis. In healthy cells, Bmf associates with the Dynein light chain 2 (DLC2), a component of the myosin V motors, and is sequestered by the cells actin cytoskeleton. Disruption of the actin cytoskeleton triggers release and activation of Bmf, initiating the downstream apoptotic program.