产品名称：CCR5 (NT), pAb
Long Term Storage: +4°C
Immunogen: Synthetic peptide corresponding to the sequence near the N-terminus of human CCR5.
Application: Immunohistochemistry (20µg/ml)
Western Blot (1:1000-1:2000)
Optimal conditions must be determined individually for each application.
Specificity: Recognizes human CCR5. Detects a band of ~40kDa by Western blot.
Purity Detail: DEAE purified.
Formulation: Liquid. In PBS containing 0.02% sodium azide.
Miscellaneous/General: Human immunodeficiency virus (HIV) requires co-receptors, in addition to CD4, to infect target cells. Some G protein coupled receptors such as CCR5, CCR4, CCR3, CCR2b, and CCR8 have been identified as HIV co-receptors. Among them, CCR5 (CCCKR-5) is a principal co-receptor for macrophage- and dual-tropic HIV-1 strains fusion and entry of human white blood cells. CCR5 is required for the infection by HIV-1, HIV-2, and SIV. The amino-terminal domain and the extracellular loops of CCR5 serve as HIV binding sites.