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 [pTyr1068]EGF receptor, pAb
  • [pTyr1068]EGF receptor, pAb
  • [pTyr1068]EGF receptor, pAb

    参考价格: ¥3750.00
    品  牌:ENZO
    产品型号:ADI-905-707-100 (100 ug)
    所在地区:上海
    上架时间:2013年03月01日
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    [pTyr1068]EGF receptor, pAb
    产品名称:[pTyr1068]EGF receptor, pAb
    规格:100 ug
    货号:ADI-905-707-100
    厂商:ENZO
    产品介绍:
    Alternative Name: EGFR, epidermal growth factor receptor
    Host: Rabbit
    Long Term Storage: -20°C  
    Immunogen: Synthetic peptide corresponding to human EGFR phosphorylated at Tyr1068.
    Application: Western Blot (1µg/ml, ECL)
    Optimal conditions must be determined individually for each application.
    Specificity: Recognizes human and (rat) EGF Receptor. Detects a band of ~170kDa by Western blot.
    Purity Detail: Peptide affinity purified.
    Formulation: Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
    Miscellaneous/General: The epidermal growth factor receptor (EGFR) is a 170-kDa membrane bound receptor consisting of an extracellular ligand-binding domain, a single hydrophobic transmembrane region, and a tyrosine kinase domain-containing cytoplasmic region. Ligand binding induces receptor homo- or heterodimerization, triggering autophosphorylation of cytoplasmic tyrosine residues that provide docking sites for Src homology 2 (SH2) domain-containing signaling molecules. Src-mediated phosphorylation of EGFR at Tyr845 may contribute to EGFR hyperactivity in cancer, while autophosphorylation of EGFR at Tyr1068 and/or Tyr1173 in response to ligand binding is known to recruit cofactors (e.g. SHP1, RasGAP, SOS1, Grb2) that activate pathways associated with cell growth, apoptosis, adhesion, receptor endocytosis, and protein degradation.