产品名称：[pTyr1068]EGF receptor, pAb
Alternative Name: EGFR, epidermal growth factor receptor
Long Term Storage: -20°C
Immunogen: Synthetic peptide corresponding to human EGFR phosphorylated at Tyr1068.
Application: Western Blot (1µg/ml, ECL)
Optimal conditions must be determined individually for each application.
Specificity: Recognizes human and (rat) EGF Receptor. Detects a band of ~170kDa by Western blot.
Purity Detail: Peptide affinity purified.
Formulation: Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
Miscellaneous/General: The epidermal growth factor receptor (EGFR) is a 170-kDa membrane bound receptor consisting of an extracellular ligand-binding domain, a single hydrophobic transmembrane region, and a tyrosine kinase domain-containing cytoplasmic region. Ligand binding induces receptor homo- or heterodimerization, triggering autophosphorylation of cytoplasmic tyrosine residues that provide docking sites for Src homology 2 (SH2) domain-containing signaling molecules. Src-mediated phosphorylation of EGFR at Tyr845 may contribute to EGFR hyperactivity in cancer, while autophosphorylation of EGFR at Tyr1068 and/or Tyr1173 in response to ligand binding is known to recruit cofactors (e.g. SHP1, RasGAP, SOS1, Grb2) that activate pathways associated with cell growth, apoptosis, adhesion, receptor endocytosis, and protein degradation.