产品名称：AIB1, mAb (50B6)
Long Term Storage: -20°C
Immunogen: Recombinant human AIB1.
Application: Western Blot (1µg/ml, ECL)
Optimal conditions must be determined individually for each application.
Specificity: Recognizes human AIB1. Detects a band of ~160kDa by Western blot.
Purity Detail: Protein G affinity purified.
Formulation: Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
Miscellaneous/General: AIB1 is a member of the p160/steroid receptor coactivator (SRC) family, named for its common amplification in breast cancer. Members of this family include a defined nuclear receptor box motif (LxxLL) that is critical for binding to nuclear hormone receptors, and two C-terminal activation domains that bind secondary coactivators such as the p300/CREB binding protein (CBP) and CARM-1 to confer acetyltransferase or methyltransferase downstream signals, respectively. AIB1 binds to estrogen receptor (ER), and its overexpression in hormone-responsive cancers and frequent amplification in breast and other cancers make it a focus for the treatment of cancer and the study of hormone receptor signaling.