上海浩洋生物科技有限公司

 AIB1, mAb (50B6)
  • AIB1, mAb (50B6)
  • AIB1, mAb (50B6)

    参考价格: ¥3750.00
    品  牌:ENZO
    产品型号:ADI-905-706-100 (100 ug)
    所在地区:上海
    上架时间:2013年03月01日
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    AIB1, mAb (50B6)
    产品名称:AIB1, mAb (50B6)
    规格:100 ug
    货号:ADI-905-706-100
    厂商:ENZO
    产品介绍:
    Clone: 50B6
    Host: Mouse
    Long Term Storage: -20°C  
    Immunogen: Recombinant human AIB1.
    Application: Western Blot (1µg/ml, ECL)
    Optimal conditions must be determined individually for each application.
    Specificity: Recognizes human AIB1. Detects a band of ~160kDa by Western blot.
    Purity Detail: Protein G affinity purified.
    Formulation: Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
    Miscellaneous/General: AIB1 is a member of the p160/steroid receptor coactivator (SRC) family, named for its common amplification in breast cancer. Members of this family include a defined nuclear receptor box motif (LxxLL) that is critical for binding to nuclear hormone receptors, and two C-terminal activation domains that bind secondary coactivators such as the p300/CREB binding protein (CBP) and CARM-1 to confer acetyltransferase or methyltransferase downstream signals, respectively. AIB1 binds to estrogen receptor (ER), and its overexpression in hormone-responsive cancers and frequent amplification in breast and other cancers make it a focus for the treatment of cancer and the study of hormone receptor signaling.