产品名称：Bradykinin receptor B2, pAb
Alternative Name: B2BKR
Long Term Storage: -20°C
Immunogen: Synthetic peptide corresponding to the sequence near the N-terminus of rat bradykinin receptor B2.
Application: ELISA (Membrane)
Optimal conditions must be determined individually for each application.
Specificity: Recognizes mouse and rat bradykinin receptor B2. Predicted MW of ~45kDa. Higher MW species (~50kDa) and intermediates also observed by Western blot which reflect post-translational modification or dimerization of the receptor. Predicted species reactivity based on epitope sequence homology: guinea pig, dog.
Purity Detail: Peptide affinity purified.
Formulation: Liquid. In PBS containing 50% glycerol and 0.01% sodium azide.
Miscellaneous/General: Bradykinin (BK) is a nine-amino acid peptide produced by kallikrein cleavage of kininogen precursor proteins in tissue and plasma, and is an important regulator of vascular and pain responses to tissue injury. Two receptors (B1 and B2) have been identified as mediators of BK signaling, and are both seven-transmembrane domain-containing GPCRs. The B2 receptor is constitutively expressed in smooth muscle and neurons, whereas B1 expression is induced following injury. B2 receptors signal via Gq alpha subunits, leading to activation of phospholipase Cbeta, hydrolysis of PI, and an intracellular increase in free calcium, although coupling through Gi, Gs, and G12/13 has also been observed.