上海浩洋生物科技有限公司

 Substance P receptor NK1, pAb
  • Substance P receptor NK1, pAb
  • Substance P receptor NK1, pAb

    参考价格: ¥3750.00
    品  牌:ENZO
    产品型号:ADI-905-801-100 (100 ug)
    所在地区:上海
    上架时间:2013年03月04日
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    Substance P receptor NK1, pAb
    产品名称:Substance P receptor NK1, pAb
    规格:100 ug
    货号:ADI-905-801-100
    厂商:ENZO
    产品介绍:
    Host: Rabbit
    Long Term Storage: -20°C 
    Immunogen: Synthetic peptide corresponding to the sequence near the N-terminus of rat substance P receptor NK1.
    Application: ELISA (Membrane)
    Western Blot
    Optimal conditions must be determined individually for each application.
    Specificity: Recognizes rat substance P receptor NK1. Predicted MW of ~46kDa. Higher MW species (~50kDa) and intermediates also observed by Western blot which reflect post-translational modification of the receptor. Predicted species reactivity based on epitope sequence homology: mouse, human, gerbil, opossum, chimpanzee, guinea pig, bovine, rhesus macaque, dog, guinea pig, Gallus.
    Purity Detail: Peptide affinity purified.
    Formulation: Liquid. In PBS containing 50% glycerol and 0.01% sodium azide.
    Miscellaneous/General: Substance P (SP) is an 11 amino acid member of the tachykinin family of neuropeptides which includes SP, neurokinin-A (NK-A) and neurokinin-B (NK-B), all of which exhibit a common COOH-terminal pentapeptide sequence Phe-X-Gly-Leu-Met-NH2. SP functions as a neurotransmitter and its effects are associated with physiological processes such as vomiting, pain, and vasodilation. Three tachykinin receptors have been identified to date, NK1, NK2, and NK3, with SP showing preferential affinity for the NK1 receptor. SP signaling occurs primarily via coupling of Gq/11 alpha subunits to NK1, leading to phospholipase C activation. High SP concentrations may also stimulate adenylyl cyclase activity, resulting in elevated cAMP.