产品名称：Substance P receptor NK1, pAb
Long Term Storage: -20°C
Immunogen: Synthetic peptide corresponding to the sequence near the N-terminus of rat substance P receptor NK1.
Application: ELISA (Membrane)
Optimal conditions must be determined individually for each application.
Specificity: Recognizes rat substance P receptor NK1. Predicted MW of ~46kDa. Higher MW species (~50kDa) and intermediates also observed by Western blot which reflect post-translational modification of the receptor. Predicted species reactivity based on epitope sequence homology: mouse, human, gerbil, opossum, chimpanzee, guinea pig, bovine, rhesus macaque, dog, guinea pig, Gallus.
Purity Detail: Peptide affinity purified.
Formulation: Liquid. In PBS containing 50% glycerol and 0.01% sodium azide.
Miscellaneous/General: Substance P (SP) is an 11 amino acid member of the tachykinin family of neuropeptides which includes SP, neurokinin-A (NK-A) and neurokinin-B (NK-B), all of which exhibit a common COOH-terminal pentapeptide sequence Phe-X-Gly-Leu-Met-NH2. SP functions as a neurotransmitter and its effects are associated with physiological processes such as vomiting, pain, and vasodilation. Three tachykinin receptors have been identified to date, NK1, NK2, and NK3, with SP showing preferential affinity for the NK1 receptor. SP signaling occurs primarily via coupling of Gq/11 alpha subunits to NK1, leading to phospholipase C activation. High SP concentrations may also stimulate adenylyl cyclase activity, resulting in elevated cAMP.