产品名称：α-Actinin, mAb (7A4)
Alternative Name: ACTN1
Long Term Storage: -20°C
Immunogen: Recombinant human α-actinin (aa 650-893).
Application: Western Blot (1:100,000)
Optimal conditions must be determined individually for each application.
Specificity: Recognizes human α-Actinin. Detects a band of ~98kDa (full length) by Western blot.
Purity Detail: Protein G-affinity purified.
Formulation: Liquid. In PBS, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Miscellaneous/General: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.