产品名称：Jnk1, mAb (2C6)
Alternative Name: SAPK, MAPK8
Long Term Storage: -20°C
Immunogen: Recombinant human Jnk1 (aa 1-384).
Application: Western Blot (1:1000)
Optimal conditions must be determined individually for each application.
Specificity: Recognizes human Jnk1. Detects a band of ~45kDa (full length) by Western blot.
Purity Detail: Protein G affinity purified.
Formulation: Liquid. In PBS, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Miscellaneous/General: JNK1 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. JNK1 is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of JNK1 by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. JNK1 is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of JNK1 gene suggested that it play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.