Alternative Name: DR, Death Receptor, TRAIL R4
Long Term Storage: +4°C
Immunogen: Synthetic peptide corresponding to a portion of human DcR2.
Application: Immunocytochemistry (10µg/ml)
Western Blot (1:1000-1:2000)
Optimal conditions must be determined individually for each application.
Specificity: Recognizes human, mouse and rat DcR2. Detects a band of ~36kDa by Western blot.
Purity Detail: Peptide affinity purified.
Formulation: Liquid. In PBS containing 0.02% sodium azide.
Miscellaneous/General: Decoy receptors (DcRs) are signaling-deficient receptors for certain members of the TNF family of cytokines, including TRAIL/Apo2L and FasL. Functional TRAIL receptors such as DR4 and DR5 transmit apoptotic signals via their intracellular death domains. In contrast, three identified TRAIL decoy receptors (DcR1, DcR2, and osteoprotegerin/OPG) completely or partially lack the signaling death domain, and/or are secreted from cells and unable to transmit intracellular signals. Thus, expression of DcRs promotes survival by sequestration of apoptotic ligands. A fourth identified decoy receptor, DcR3, binds both FasL and the vascular endothelial cell growth inhibitor (VEGI), inhibiting Fas and DR3 death signals.