Alternative Name: Second mitochondria-derived activator of caspase
Long Term Storage: -20°C
Immunogen: Recombinant human Smac/DIABLO .
Application: Western Blot (1-2µg/ml, ECL)
Optimal conditions must be determined individually for each application.
Specificity: Recognizes human, mouse, rat and hamster Smac/DIABLO.
Purity Detail: Protein G affinity purified.
Formulation: Liquid. In PBS containing 50% glycerol.
Miscellaneous/General: Smac/DIABLO is one of the pro-apoptotic proteins normally found in the intermembrane space of the mitochondria. In response to apoptotic stimuli, Smac/DIABLO is released into the cytosol resulting in permeabilization of the mitochondrial membrane. Cytosolic Smac/DIABLO activates caspase-9 by binding IAP proteins. Changes in the expression level of Smac/DIABLO have been demonstrated in a number of human cancers including melanoma, ovary, and prostate.