上海浩洋生物科技有限公司

 ASK1, pAb
  • ASK1, pAb
  • ASK1, pAb

    参考价格: ¥4050.00
    品  牌:ENZO
    产品型号:ADI-AAP-480-E (100 ug)
    所在地区:上海
    上架时间:2013年03月04日
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    ASK1, pAb
    产品名称:ASK1, pAb
    规格:100 ug
    货号:ADI-AAP-480-E
    厂商:ENZO
    产品介绍:
    Host: Rabbit
    Long Term Storage: +4°C  
    Immunogen: Synthetic peptide corresponding to the sequence near the C-terminus of human ASK1. The sequence differs from mouse ASK1 by two amino acids.
    Application: Immunocytochemistry (10µg/ml)
    Western Blot (1:500-1:1000)
    Optimal conditions must be determined individually for each application.
    Specificity: Recognizes human ASK1. Detects a band of ~155kDa by Western blot.
    Purity Detail: Peptide affinity purified.
    Formulation: Liquid. In PBS containing 0.02% sodium azide.
    Miscellaneous/General: Apoptosis signal-regulating kinase 1 (ASK1), also known as MAPKKK5 is a member of the MAPKKK family. ASK1 activates two different subgroups of MAPKK, MKK4, and MKK6, which in turn activate c-Jun N-terminal kinase (Jnk) and p38 MAP kinase, respectively. ASK1/MAPKKK5 is activated by TNF-R and Fas through the interaction with members of the TRAF family and the Fas-associated protein Daxx. Overexpression of ASK1 induces apoptotic cell death, and a catalytically inactive form of ASK1 inhibits TNF-alpha-induced apoptosis. ASK1 is expressed in a variety of human and mouse tissues.