Alternative Name: Transporter Associated with Antigen Processing 1
Long Term Storage: -20°C
Immunogen: Synthetic peptide corresponding to a portion of human TAP1 .
Application: Immunohistochemistry (paraffin sections)
Western Blot (ECL, 1:4000)
Optimal conditions must be determined individually for each application.
Specificity: Recognizes human and rat TAP1. Detects a band of ~70kDa by Western blot.
Formulation: Liquid. Whole rabbit serum.
Miscellaneous/General: TAP1 and TAP2 are two structurally related subunits of the Transporter associated with antigen processing (TAP). The TAP complex is a member of the ATP binding cassette (ABC) family of transmembrane transporters. The TAP transporter is an essential component of the MHC class I antigen presentation pathway by binding peptides in its cytosolic part and subsequently translocating the peptides into the lumen of the endoplasmic reticulum where assembly of MHC class I and pepide takes place.