Alternative Name: BCL2-associated X protein
Long Term Storage: -20°C
Immunogen: Synthetic peptide corresponding to a portion of human Bax.
Application: Western Blot (1:1000, ECL)
Optimal conditions must be determined individually for each application.
Specificity: Recognizes human, mouse, rat, bovine, monkey, pig and rabbit Bax. Detects a band of ~22kDa by Western blot.
Purity Detail: Protein A affinity purified.
Formulation: Liquid. In PBS containing 50% glycerol and 0.09% sodium azide.
Miscellaneous/General: Bax is an appromimately 22 kDa pro-apoptotic protein belonging to the Bcl-2 family of proteins, which are characterized by the presence of at least one Bcl-2 homology (BH) domains. Bax normally resides in the cytoplasm, but following an apoptotic stimuli, Bax undergoes a conformational change and translocates to mitochondrial membranes where it inserts and mediates the release of cytochrome c. This activates caspase-3 and perpetuates the apoptotic cascade.