上海浩洋生物科技有限公司

 Bcl-2, pAb
  • Bcl-2, pAb
  • Bcl-2, pAb

    参考价格: ¥3450.00
    品  牌:ENZO
    产品型号:ADI-AAS-070-E (100 ug)
    所在地区:上海
    上架时间:2013年03月05日
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    Bcl-2, pAb
    产品名称:Bcl-2, pAb
    规格:100 ug
    货号:ADI-AAS-070-E
    厂商:ENZO
    产品介绍:
    Host: Rabbit
    Long Term Storage: -20°C  
    Immunogen: Synthetic peptide corresponding to a portion of human Bcl-2.
    Application: Immunoprecipitation (1:100)
    Western Blot (1µg/ml, ECL)
    Optimal conditions must be determined individually for each application.
    Specificity: Recognizes human and monkey Bcl-2. Detects a band of ~25kDa by Western blot.
    Purity Detail: Protein A affinity purified.
    Formulation: Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
    Miscellaneous/General: Bcl-2 alpha and beta are alternatively spliced isoforms of 25 kDa and 22 kDa integral membrane proteins that typically inhibit apoptosis; however Bcl-2 can also be pro-apoptotic. Bcl-2 is found in the mitochondrial, ER and nuclear membranes, and its subcellular location appears to affect whether it is pro-apoptotic or anti-apoptotic. Bcl-2 becomes pro-apoptotic when it is either cleaved by caspase-3 or targeted to the mitochondrial membrane. When Bcl-2 is targeted to the ER membrane, it protects cells from apoptosis induced by Bax overexpression. ER membrane Bcl-2 may protect against apoptosis by preserving the integrity of the mitochondria after an apoptotic stimulus. Bcl-2 family members are characterized by at least one of four Bcl-2 homology domains (BH1-BH4). Anti-apoptotic Bcl-2 proteins contain BH1-BH4 while pro-apoptotic proteins contain either BH1-BH3 or BH3 alone (e.g., Bad, Bid).