上海浩洋生物科技有限公司

 Fas, pAb
  • Fas, pAb
  • Fas, pAb

    参考价格: ¥2700.00
    品  牌:ENZO
    产品型号:ADI-AAP-221-D (50 ug)
    所在地区:上海
    上架时间:2013年03月05日
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    Fas, pAb
    产品名称:Fas, pAb
    规格:50 ug
    货号:ADI-AAP-221-D
    厂商:ENZO
    产品介绍:
    Host: Rabbit
    Long Term Storage: -20°C 
    Immunogen: Synthetic peptide corresponding to a portion of mouse Fas. 
    Application: Immunohistochemistry (1:50)
    Western Blot (1:1000, ECL)
    Optimal conditions must be determined individually for each application.
    Specificity: Recognizes human, mouse and rat Fas. Detects a band of ~45kDa by Western blot.
    Purity Detail: Peptide affinity purified.
    Formulation: Liquid. In PBS, pH 7.2, containing 0.09% sodium azide.
    Miscellaneous/General: Fas/APO-1/CD95 is a 36 kDa cell surface type I-membrane glycoprotein with an apparent molecular weight of 44 kDa on SDS-PAGE.  Fas belongs to the tumor necrosis factor receptor (TNFR) family, which includes TNFR1, TNFR2, CD27, CD30 and CD40.  Binding of Fas-ligand (FasL) to Fas or crosslinking of Fas by anti-Fas monoclonal antibodies leads to apoptosis of Fas expressing cells.  Both Fas and TNFR contain a 70 amino acid cytoplasmic “death domain” responsible for transmitting signals for apoptosis.  Apoptosis induced by Fas-Fas ligand interaction is inhibited by a number of cytosolic factors such as the ICE/CED3 family inhibitor CrmA, and the short and long forms of FLIP. Insertion of an early transposable element in intron 2 of the Fas gene, as in the mouse lpr mutations, causes lymphoproliferation and autoimmunity in mutant mice, suggesting the involvement of Fas in clonal deletion of autoreactive T cells.
    ENZO ADI-AAP-221-D Fas, pAb 50 ug 2700
    ENZO ADI-AAP-221-F Fas, pAb 200 ug 5250