产品名称：GSK-3α/β, mAb (1H8)
Alternative Name: glycogen synthase kinase
Long Term Storage: -20°C
Immunogen: Recombinant Xenopus GSK-3β.
Western Blot (1:1000, colorimetric)
Optimal conditions must be determined individually for each application.
Specificity: Recognizes human, mouse, rat, bovine, dog, hamaster, monkey, pig, rabbit and sheep GSK-3α/β. Detects bands of ~51 and ~47kDa by Western blot.
Purity Detail: Protein G affinity purified.
Formulation: Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
Miscellaneous/General: Glycogen Synthase Kinase 3beta (GSK-3beta) is a unique serine/threonine kinase that is inactivated by phosphorylation. In response to insulin binding, PKB/AKT phosphorylates GSK-3beta on serine 9, which prevents GSK-3beta from phosphorylating glycogen synthase. Unphosphorylated glycogen synthase is active and able to synthesize glycogen. GSK-3beta is also unique in that it requires a substrate that has been phosphorylated by a distinct kinase before it can phosphorylate the substrate. This phosphate priming mechanism explains why phosphorylation of serine 9 inactivates GSK-3beta.
ENZO ADI-KAM-ST002-D GSK-3α/β, mAb (1H8) 50 ug 2550
ENZO ADI-KAM-ST002-F GSK-3α/β, mAb (1H8) 200 ug 5100