Alternative Name: glycogen synthase kinase
Long Term Storage: -20°C
Immunogen: Synthetic peptide corresponding to a portion of rat GSK-3β. The sequence is completely conserved in human.
Immunohistochemistry (paraffin sections)
Western Blot (1:1000, colorimetric)
Optimal conditions must be determined individually for each application.
Specificity: Recognizes human, mouse, rat and bovine GSK-3β. Detects a band of ~47kDa by Western blot.
Purity Detail: Protein A affinity purified.
Formulation: Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
Miscellaneous/General: Glycogen Synthase Kinase 3beta (GSK-3beta) is a unique serine/threonine kinase that is inactivated by phosphorylation. In response to insulin binding, PKB/AKT phosphorylates GSK-3beta on serine 9, which prevents GSK-3beta from phosphorylating glycogen synthase. Unphosphorylated glycogen synthase is active and able to synthesize glycogen. GSK-3beta is also unique in that it requires a substrate that has been phosphorylated by a distinct kinase before it can phosphorylate the substrate.
ENZO ADI-KAP-ST002-C GSK-3β, pAb 25 ug 1800
ENZO ADI-KAP-ST002-E GSK-3β, pAb 100 ug 3750