Alternative Name: interleukin-1 receptor-associated kinase
Long Term Storage: +4°C
Immunogen: Synthetic peptide corresponding to the sequence near the C-terminus of human IRAK-M.
Application: Immunohistochemistry (2µg/ml)
Western Blot (0.5-1.0µg/ml)
Optimal conditions must be determined individually for each application.
Specificity: Recognizes human, mouse and rat IRAK-M. Detects a band of ~68kDa by Western blot.
Purity Detail: Peptide affinity purified.
Formulation: Liquid. In PBS containing 0.02% sodium azide.
Miscellaneous/General: IRAK (IL-1 associated serine/threonine kinase) is a critical regulator of IL-1 induced activation of the NFkappaB pathway. IL-1 stimulates the association of IRAK with the heterodimer of IL-IRI and IL-IRAcP via the adapter protein MyD88. In addition to its role in IL-1 signaling, IRAK is a component of the signal transduction pathway through which TNF-R1 activates NFkappaB dependent gene expression.