Long Term Storage: -20°C
Immunogen: Synthetic peptide corresponding to a portion of human c-Jun.
Western Blot (1µg/ml, ECL)
Optimal conditions must be determined individually for each application.
Specificity: Recognizes human, mouse, rat, bovine, dog, chicken, Drosophila, guinea pig, hamster, monkey, pig, rabbit, sheep and Xenopus c-Jun. Detects a band of ~46kDa by Western blot.
Purity Detail: Peptide affinity purified.
Formulation: Liquid. In PBS containing 0.02% sodium azide.
Miscellaneous/General: c-Jun, a component of the AP1 transcriptional apparatus, forms homo/heterodimers with Jun, Fos, ATF, or other trancriptional factors through its leucine zipper domain. The activity of c-Jun is enhanced upon by phosphorylation of serine 63 and serine 73 residues by Jnk (c-Jun N-Terminal Kinase). Signals relayed by Jnk through c-Jun regulate a range of cellular processes including cell proliferation, tumorigenesis, apoptosis, and embryonic development. Studies have shown that c-Jun plays an important role in neuronal apoptosis, regeneration, and protection.