上海浩洋生物科技有限公司

 293XL/mTLR7
  • 293XL/mTLR7
  • 293XL/mTLR7

    参考价格: ¥10304.00
    品  牌:invivogen
    产品型号:293xl-mtlr7 (5-7 x 10e6 cells)
    所在地区:上海
    上架时间:2013年03月14日
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    293XL/mTLR7
    产品名称:293XL/mTLR7
    规格:5-7 x 10e6 cells
    货号:293xl-mtlr7
    厂商:invivogen
    产品介绍:
    Antibiotic resistance: blasticidin
    Growth medium: DMEM, 4.5 g/l glucose, 2-4 mM L-glutamine, 10% (v/v) fetal bovine serum, 50 U/ml penicillin, 50 μg/ml streptomycin, 100 μg/ml Normocin™
    Guaranteed mycoplasma-free
    Shipped on dry ice
    293XL/TLR7 cells were obtained by stable transfection of HEK293XL cells with a pUNO-TLR7 plasmid which expresses the human or murine TLR7 gene.
    1 vial containing 3-7 x 106 cells
    100 μl Blasticidin (10 mg/ml)
    1 ml Normocin™ (50 mg/ml)
    TLR7, which is abundantly expressed in lung, placenta, spleen and PBL, is phylogenetically close to TLR8 and TLR9 [1]. TLR7 recognizes small synthetic molecules such as loxoribine and R848, an imidazoquinoline compound [2]. TLR7 signaling involves the MyD88-dependent signaling cascade and induces the production of IFN-α, TNF-α and IL-12. Recently, single-stranded RNA (ssRNA) was identified as the natural ligand of TLR7 [3, 4]. ssRNA derived from HIV-1 or the influenza virus were shown to induce the production of proinflammatory cytokines in PDC. TLR7 signaling is abrogated by chloroquine indicating that it is dependent on endosomal acidification.