上海浩洋生物科技有限公司

HKLP

HKLP

参考价格:¥1806.00
品  牌:invivogen
产品型号:tlrl-hklp (10e9 cells)
所在地区:上海
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HKLP
产品名称:HKLP
规格:10e9 cells
货号:tlrl-hklp
厂商:invivogen
产品介绍:
Specificity: TLR2 agonist
Working concentration: 107-108 cells/ml
Endotoxin level: EndoFit™ (<0.001 EU/μg)
Solubility: Insoluble (resuspended HKLP results in a cloudy suspension)
HKLP is provided lyophilized and shipped at room temperature. Store at 4°C. Upon resuspension, prepare aliquots of HKLP and store at 4° C for short term storage or -20° C for long storage. Resuspended product is stable 1 month at 4° C and 6 months at -20° C when properly stored.
Legionella pneumophila, a Gram negative bacterium, is the causative agent of legionnaires’ disease which is characterized by severe pneumonia. Although TLR4 is involved in host defense against gram negative bacteria infection, it is not activated or is activated only to a limited extent by L.pneumophila [1]. L. pneumophila requires TLR2 rather than TLR4 to induce the production of cytokines [2]. Stimulation with heat-killed L. pneumophila (HKLP) induces the activation of NF-κB in TLR2-expressing HEK293 cells but not in TLR4-expressing HEK293 cells.