Specificity: TLR2 agonist
Working concentration: 108-109 cells/ml
Endotoxin level: >1 EU/109 cells
Solubility: Insoluble (resuspended HKLR results in a cloudy suspension)
HKLR is provided lyophilized and shipped at room temperature. Store at 4°C. Upon resuspension, prepare aliquots of HKLR and store at 4°C for short term storage or -20°C for long storage. Product is stable 1 month at 4°C and 6 months at -20°C when properly stored.
Lactobacillus rhamnosus is a nonpathogenic gram-positive inhabitant of the human microflora. It is used as a natural preservative in yogurt and other dairy products to extend the shelf life. Lactobacillus rhamnosus is known to have beneficial health effects, such as the nonspecific enhancement of the immune system. Indeed, heat-killed Lactobacillus rhamnosus (HKLR) has been shown to be a potent inducer of TNF-α from mouse mononuclear cells. This immune response is dependent on TLR2 and CD14 .