Working concentration: 0.5 µM
CAS number: 391210-10-9
Purity: >98% (HPLC)
Molecular weight: 482.19
Solubility: DMSO, ethanol, DMF (20 mg/ml)
PD0325901 is a synthetic organic molecule that selectively binds to and inhibits mitogen-activated protein kinase kinase (MEK). The MEK/ERK signaling pathway plays an important role in the self-renewing state of ES cells . Inhibition of this pathway combined with the inhibition of other signaling pathways has been shown to improve the efficiency of iPS cell generation. Combination of PD0325901 with a TGF-β receptor inhibitor was found to improve the reprogramming of OSKM-infected human fibroblasts .