Working concentration: 50-100 μM
CAS number: 167869-21-8
Molecular weight: 267.28
Solubility: DMSO (6.5 mg/ml), ethanol (0.6 mg/ml)
Purity: >99% (HPLC, TLC)
PD98059 is a potent and selective inhibitor of MAP kinase kinase (also known as MAPK/ERK kinase or MEK kinase) . It mediates its inhibitory properties by binding to the ERK-specific MAP kinase MEK, therefore preventing phosphorylation of ERK1/2 (p44/p42 MAPK) by MEK1/2. MAPK ERK1/2 is involved in TLR-induced production of cytokines[2, 3].