上海浩洋生物科技有限公司

 Wortmannin
  • Wortmannin
  • Wortmannin

    参考价格: ¥1512.00
    品  牌:invivogen
    产品型号:tlrl-wtm (5 mg)
    所在地区:上海
    上架时间:2013年03月18日
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    Wortmannin
    产品名称:Wortmannin
    规格:5 mg
    货号:tlrl-wtm
    厂商:invivogen
    产品介绍:
    Working concentration:
    0.1-2.5 μM when used as an inhibitor in the TLR signaling cascade
    0.1-10 μM when used as an inhibitor of autophagosome formation
    Purity: >99% (HPLC)
    Endotoxin level: <0.125 EU/mg
    Solubility: 10 mM in DMSO or methanol
    CAS number: 19545-26-7
    Synonym: KY 12420
    Molecular weight: 428.4
    Wortmannin is a cell-permeable, fungal metabolite that acts as a potent, selective and irreversible inhibitor of phosphatidylinositol 3-kinase (PI3K) [1].
    There is increasing evidence of the involvement of PI3K in Toll-like receptor (TLR) signaling [2]. Inhibition of PI3K with wortmannin enhances TLR-mediated inducible nitric-oxide synthase (iNOS) expression, activates NF-κB and up-regulates cytokine mRNA production [3].
    Furthermore, PI3K is required for autophagy [4]. Autophagy is a complex pathway in which cell material can be sequestered and delivered to the lysosome for degradation. Inhibition of PI3K with wortmannin can inhibit autophagic sequestration [4].