上海浩洋生物科技有限公司

Wortmannin

Wortmannin

参考价格:¥1512.00
品  牌:invivogen
产品型号:tlrl-wtm (5 mg)
所在地区:华东 上海
留言咨询
与企业取得联系时请告知该信息获取自中国教育装备采购网
我要分享
详细说明

Wortmannin
产品名称:Wortmannin
规格:5 mg
货号:tlrl-wtm
厂商:invivogen
产品介绍:
Working concentration:
0.1-2.5 μM when used as an inhibitor in the TLR signaling cascade
0.1-10 μM when used as an inhibitor of autophagosome formation
Purity: >99% (HPLC)
Endotoxin level: <0.125 EU/mg
Solubility: 10 mM in DMSO or methanol
CAS number: 19545-26-7
Synonym: KY 12420
Molecular weight: 428.4
Wortmannin is a cell-permeable, fungal metabolite that acts as a potent, selective and irreversible inhibitor of phosphatidylinositol 3-kinase (PI3K) [1].
There is increasing evidence of the involvement of PI3K in Toll-like receptor (TLR) signaling [2]. Inhibition of PI3K with wortmannin enhances TLR-mediated inducible nitric-oxide synthase (iNOS) expression, activates NF-κB and up-regulates cytokine mRNA production [3].
Furthermore, PI3K is required for autophagy [4]. Autophagy is a complex pathway in which cell material can be sequestered and delivered to the lysosome for degradation. Inhibition of PI3K with wortmannin can inhibit autophagic sequestration [4].