Species: human, mouse, bovine, pig
TLR5 is the Toll-like molecule that recognizes flagellin from both Gram-positive and Gram-negative bacteria.
TLR5 was identified by the presence of the TIR domain and is expressed in spleen, peripheral blood leukocytes and epithelial cells.
Activation of the receptor stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88 and the serine kinase IRAK [1, 2]. TLR5 can generate a proinflammatory signal as a homodimer suggesting that it might be the only TLR required for flagellin recognition .
invivogen puno1-htlr5 pUNO1-hTLR05 1 disk 5334
invivogen puno1ha-htlr5 pUNO1-hTLR05-HA3x 1 disk 5698