Species: human, mouse
TLR8 was identified together with TLR7 and TLR9 and is expressed more abundantly in PBL and lung .
The natural ligand for TLR8 is still unknown. Human TLR8 and TLR7 were reported to independently confer responsiveness to R848, an imidazoquinoline compound with antiviral activity. Upon R848 stimulation, HEK293 cells transfected with human TLR8 induced NF-κB activation in a dose-dependent manner .
In contrast, HEK293 cells expressing murine TLR8 were hyporesponsive to R848 suggesting that TLR8 is nonfunctional in mice.
invivogen puno1-htlr8b pUNO1-hTLR08b 1 disk 5334
invivogen puno1ha-htlr8b pUNO1-hTLR08b-HA3x 1 disk 5698