上海浩洋生物科技有限公司

 Cell Meter Autophagy Assay Kit
  • Cell Meter Autophagy Assay Kit
  • Cell Meter Autophagy Assay Kit

    参考价格: ¥2340.00
    品  牌:AAT Bioquest
    产品型号:AAT-23000 (1 kit)
    所在地区:上海
    上架时间:2013年04月15日
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    Cell Meter Autophagy Assay Kit
    产品名称:Cell Meter Autophagy Assay Kit
    产品货号:AAT-23000
    产品价格:¥2340
    产品规格:1 kit
    Ex (nm):333            Em (nm):518
    Storage:F/D/L (see storage codes below)
    Autophagy is an evolutionarily conserved degradation process that targets long-lived proteins, organelles, and other cytoplasmic components for degradation via the lysosomal pathway. The autophagy pathway is complementary to the action of the ubiquitin-proteasome pathway which typically degrades short-lived proteins. Activation of the autophagy pathway is required for multiple cellular roles, including survival during starvation, the clearance of intracellular components, development, and immunity. In the absence of stress, autophagy serves a house-keeping function, removing damaged organelles and cellular components preventing cytotoxic effects. Decreases and defects in autophagy have been implicated in multiple diseases, for example Huntingtons, Alzheimers, and Parkinsons. In terms of cancer development, autophagy seems to play multiple roles. Decreased or absent expression of certain autophagy proteins, such as Beclin-1 and Bif-1, increases tumor susceptibility in mice while the overexpression of these proteins can repress cancer cell growth. However, autophagy is critical for the survival of cancer cells within the nutrient poor and hypoxic core of solid tumors. Cell MeterAutophagy Kit employs Autophagy Blue?as a specific autophagosome marker to analyze the activity of autophagy. The assay is optimized for direct detection of autophagy in both detached and attached cells. The kit provides all the essential components for the assay protocol. Cell MeterAutophagy Kit is suitable for fluorescence microscope, fluorescence microplate reader and flow cytometer. Autophagy Blue?has fluorescence excitation and emission at Ex/Em = 333/518 nm.
    Storage Codes:
    D = Desiccated
    L = Avoid light
    F = Freeze (<-15)
    R = Refrigerated (2-4)
    RT = Room temperature (4-50)