现货 标准品Brefeldin A/布雷菲德菌素A_中国教育装备采购网

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4008190228-0125
 现货 标准品Brefeldin A/布雷菲德菌素A
  • 现货 标准品Brefeldin A/布雷菲德菌素A
  • 现货 标准品Brefeldin A/布雷菲德菌素A

    参考价格: ¥380.00
    品  牌:chembest
    产品型号:C13399 (99%)
    适用范围:高教
    所在地区:上海
    上架时间:2018年07月30日
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    RMB:380.00/5mg

    Brefeldin A/布雷菲德菌素A
    Molecula Formula:C16H24O4
    Molecular Weight: 280.36
    Appearance: White solid
    Purity:99%
    CAS[20350-15-6]

    Biological Activity:
    Brefeldin A (BFA) is a fungal metabolite that disrupts the structure and function of the Golgi apparatus. The compound induces the Golgi proteins to redistribute into the ER and blocks the secretion from the Golgi apparatus. Studies show that it blocks the GTP-dependent interaction of ARF with the Golgi membrane, thus inhibiting the assembly of coatomer onto the membrane. Research shows that BFA can induce apoptosis in Neuroendocrine tumor cells by activating caspase-3, and inhibits cell growth by targeting the cell cycle in prostate cancer cells.

    References:
    1.Ktistakis et al (1992) Action of brefeldin A blocked by activation of a pertussis-toxin-sensitive G protein. Nature 356 344.
    2.Tsai et al (1994) Identification of a brefeldin A-insensitive guanine nucleotide-exchange protein for ADP-ribosylation factor in bovine brain. Proc.Natl.Acad.Sci.U.S.A. 91 3063.
    3.Morinaga et al (1996) Isolation of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP ribosylation factor (ARF)1 and ARF3 that contains a Sec7-like domain. Proc.Natl.Acad.Sci.U.S.A. 93 12856.
    4.Ding et al (2007) Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival. J.Biol.Chem. 282 4702.

    (产品仅适用于科学实验,不得用于其他目的).